These results indicate that 85 mg/m2 BBR 2778 in a q1w x 3 schedule is active in elderly and pretreated patients with relapsed aggressive NHL and was generally well tolerated. Thus, we recommend further clinical evaluation of this new compound in phase-III studies for the treatment of NHL.

HAZELL:QSA2778S,BGA:KS5613,VAICO:V10-7505,A.B.S.:211864 01,TRISCAN:8501 0181,BBR Automotive:001-10-18566,TRISCAN:8501 0182,BBR 

A phase-I study in patients with non-Hodgkin's lymphoma (NHL) showed that the drug has promising anti-tumor activity. Therefore, a phase-II study in patients with relapsed aggressive NHL was initiated. DESIGN AND BBR 2778 is a novel aza-anthracenedione with no cardiotoxicity in preclinical models. This Phase I dose escalation trial of BBR 2778 was conducted to determine the maximum tolerated dose, the dose-limiting toxicity, and the pharmacokinetic profile of BBR 2778 in patients with advanced solid tumors.

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HS75C. 68. 2433. 8 SK4NI. GT48D.

Pixantrone is an aza-anthracenedione and DNA intercalator which inhibits topoisomerase II. It is similar in structure to anthracyclines such as mitoxantrone, but exerts fewer toxic effects on cardiac tissue. [2] The lower cardio-toxic effects of pixantrone may be explained, in part, by its redox inactivity [3].

The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials. Cavalletti E, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone.

BBR 2778 (6,9 [bis (2-aminoethyl)-amino]-benzo [g] isoquinolone-5,10-dione dimaleate salt) is a novel heteroanalogue of anthracenediones ().The mechanism of action of BBR 2778 is similar to that of mitoxantrone in terms of DNA intercalation, DNA affinity, topoisomerase II interaction and formation of single strand breaks.

HS75C. 68. 2433.

Konsekvensutredning BBR 23 (PDF) 1,07 MB. Konsekvensutredning BBR 22 (PDF) 352 kB Se hela listan på en.wikipedia.org BBR 2778. A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics. Also called pixantrone.
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BBR avsnitt 8 ställer krav på personsäkerhet vid kontakt med glas 2778. 2917.
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Pixantrone (BBR 2778) ~ Recruitment for the phase III study in relapsed indolent NHL is underway with 100 centres being opened worldwide. This study is comparing single agent rituximab, the current standard treatment, with a pixantrone (BBR 2778)/rituximab combination. This

8 - 16. 2540. 3175. › 9 - 10. 2000.